STRESS VA IMMUN TIZIMI: FIZIOLOGIK TA’SIRI VA KASALLIKLAR BILAN BOG’LIQLIGI
Keywords:
Stress, immun tizimi, kortizol, surunkali stress, autoimmun kasalliklar, virusli infeksiya, yallig‘lanish, HPA o‘qi.Abstract
Ushbu maqolada stress va immun tizimi o‘rtasidagi murakkab bog‘liqlik tahlil qilinadi. Stress organizmning gomeostazini buzib, gipotalamus-gipofiz-buyrak usti (HPA) o‘qi va simpatik asab tizimi orqali immun javobga ta’sir ko‘rsatadi. O‘tkir stress immun tizimni qisqa muddatga faollashtirishi mumkin, biroq surunkali stress immun funksiyalarni susaytirib, virusli infeksiyalar, autoimmun kasalliklar va yallig‘lanish jarayonlarini kuchaytirishi aniqlangan. Tadqiqotlar shuni ko‘rsatadiki, stress darajasining oshishi T-hujayralar sonining kamayishi, sitokinlar balansining buzilishi va antioksidant himoyaning zaiflashishiga olib keladi. Shuningdek, maqolada stressni boshqarish usullari va immun tizimini mustahkamlashga qaratilgan strategiyalar tahlil qilinadi.
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